Astonishing Breakthrough In Nerve Regeneration Gives New Hope To Neuropathy Suffers Crossing Scientific Barriers For A New Model of Integrative Healthcare Summary Magnetic Resonance Therapy has demonstrated effectiveness in regenerating subcellular nerve stnictures. with concomitant restoration of function, in replicate studies with mice at Cornell and Fairlcigh Dickinson universities. Professors Brij and Anjali Saxena of Cornell and Fairlcigh Dickinson, respectively, said, "The loss in the inherent transmembranc potential- this electrical potential may be manipulated by an externally applied electromagnetic field, which can restore the intrinsic charge distribution of molecules vital for nerve conduction and injury, spinal cord trauma, and peripheral neuropathy ncurotropins and their receptors." Further dose-response studies to determine therapeutic models for clinical EMF applications in the treatment of nerve dysfunctions are ongoing. Through the millennia there have been special individuals gifted with a vision extending far into the future. Leonardo da Vinci saw flying machines more than three centuries before Kittyhawk. man's first flight into the heavens. Now we liave supersonic jets, and rockets that explore outer reaches of the solar system. For many years. Thomas Edison dreamed of producing light from electricity: after thousands of experiments it came to pass. Louis Pasteur dreamed of stimulating natural immune mechanisms to cure disease, and today vaccination and homeopathy arc utilized routinely to achieve wellncss. D. D Palmer, the founder of the science of Chiropractic, saw the human body as consisting of particles, atoms, or molecules. He said that these substructures of nerves vibrate, oscillate, and. when nerves arc in their normal state of tone or tension, communicating impulses are transmitted by vibration waxes in a physiologic manner with balanced force. Today, the restoration of congruent and coherent vibrational states of the fundamental particles may be regulated with magnetic resonance energies, natural to the human body. The current Standard Model of matter divides all matter into two categories: hadrons and leptons. Hadrons arc ultimately made of quarks, electrically charged, and incessantly moving, as arc leptons. Einstein said that matter is nothing more than condensations of electromagnetic field. Since all matter is composed of small units that arc electrically charged and incessantly moving, all matter possesses a magnetic profile: including all human tissues. The human body is a remarkable universe of electromagnetic design, and it is therefore understandable that magnetic forces may be utilized to regulate the microscopic constituents of the human body, to restore the normal tonicity of nerves: just as D. D. Palmer foresaw. Indeed. D.D. Palmer practiced magneto therapy. He understood that restoration of articulating structures (from a macroscopic perspective) is essential to restore normal communications between the brain and end organs (including the viscera). In addition, the reduction of luxations and subluxations is essential to eliminate excesses of stress and strain energies on nerves, and to permit restora- tion of normal vibrational patterns and communications networks. D. D Palmer also foresaw the need to rebalance bodily tissues on the microscopic level to free the atoms and molecular assemblies and sub units from deforming pressures of toxic materials and microorganisms- as well as the tensions caused by emotional, chemical and physical imbalance. We call these individuals "visionaries." All the therapeutic modalities appreciated today seek to unify macroscopic and microscopic structure and function and thus restore homcostasis on all levels, including the mesoscopic level, e.g. cellular assemblies and subunits. Today, nonnal or physiologic magnetic profiles of human tissues have been measured directly with superconducting or atomic magnetometers, and these magnetic fields have been found to be in the picoTcsla range. One picoTcsla is 50 million times weaker than the Earth's steady magnetic field. Since the atoms and molecules that comprise living tissues arc so small it is understandable why, from a microscopic point of view, the natural magnetic profiles of tissues must be subtle energies. Living systems evolved into a complex array of trillions of atoms, and our functional nature involves inherent and intrinsic regulation of these atoms through the long-range electromagnetic force: as well as stochastic chemical interactions tliat arc short range. Pico Tcsla electromagnetic fields (PTEMF"s) have been demonstrated to affect alpha and delta brain waves in humans. (1) to enhance regeneration of damaged nerves in mice, and (2) to alter atriovcntricular conduction and heart rhythm in dogs. (3) Low level EMF's also modulate endogenous opioid activity (e.g. cnkcphalin. endorphin) and pain behavioral actions in various species including humans. (4. 5.6) Clinically. PTEMFS have shown benefits in patients with joint disease, pelvic pain, and neurological disorders such as epilepsy, multiple sclerosis and Parkinson's disease. (7.8) Wound healing and regulation of spinal ncuronal potentials in rats have also been demonstrated with PTEMFs. (9) Recovery of Motorneuropathy In Mice By Applied Electromagnetic Field We have seen that the energy state and bioelectric potential of nerves may be modulated by PTEMF"s. (9) For the following studies, the field intensities, gradients and frequencies were calculated with the Jacobson Resonance equations (2.8); considering subccllular components vital for nerve function. Target molecules included nerve growth factors, dyncia kinc-sinc. microtubulc associated protein (MAP), ncurofilamcnts. tubulin. cholincstcrasc. acctylcholinc. and calmoduline. It was determined that the natural EMF profile for mice is in the micro gauss range. One micro gauss equals one hundred picoTcsla. A sequence of extremely low-level EMF magnitudes with correspondent biological frequencies (<30() Hz) was utilized. The effect of these low-level EMF"s on the restoration of fore-limb grip strength and radial nerve ultrastructurc was studied in mice with induced motorneuropathy. (2) The Control Group 1 (n=10) was neither poisoned nor treated with EMF. Groups 2 and 3 (n=20) were poisoned to induce motor neuropathy. Group 2 (n= 10) after poisoning was treated with EMF. while Group 3 was poisoned but not treated. Correlation of forclimb grip strength of all mice (n=30) at baseline was closely analogous (with no significant difference). Motorneuropathy was induced by administration of a ncuro-toxin (IDPN). in drinking water ad lib. for 9 '/: weeks. Forclimb grip strength of mice, as measured by a force gauge meter, declined to 47% compared to the Control Group 1. a significant difference (Group 2. p<().0()4; Group 3. p<().()0). The normal age related increase in grip strength in the Control Group 1 was considered for the statistical analysis. The IDPN treated Group 3( without EMF treatment) persisted to have a 56% decrease in grip strength, and radial nerve electron micrographs showed axonal denn clination. mitochondria in an orthodox state of conformation (inactive), and uneven dispersion of ncurofilamcnts and microtubulcs. In contrast. IDPN treated Group 2 (with EMF exposure) exhibited axonal rcmy clination. condensed state of mitochondria (indicative of anabolic activity) and evenly dispersed ncuro-fila- mcnts and microtubules. consistent with grip strength recovery. EMF exposure was accomplished with the prototypical Ja-cobson Resonator, built at the John C. Stennis Space Center by NASA engineers. It consisted of Hclmholtz coils. 18 inches in diameter, having an inter-coil distance of 9 inches: and the low - level uniform EMF produced in the space between the coils represented the EMF environment. Two mice at a time were held in dual-chambered (8 inch by 6 inch) Lucitc perforated boxes. EMF"s were applied twice weekly for 8 '/= weeks to Group 2 that resulted in 87 % recovery. (p<().()5) of grip strength that was sustained after termination of exposure at an 82% level until the 27th week of observation. In the absence of EMF exposure. IDPN treated Group 3 had a significantly low grip strength as compared to both EMF exposed Group 2 (PO.01) and the control Group 1 (pO.OOO) The ncurotoxin effect persisted in Group 3 with 56% lower grip strength, as compared to Control Group 1. A consistent increase in grip strength, after termination of EMF exposure, was observed in Group 2 as it approached the level of the Control Group 1. Electron micrograph of Radial Nerves: Cross Sections of Control And Experimental Groups (Figures I, II and III excerpted from Medical Hypotheses, 60(6): 821-839) Discussion The gradual loss in forelimb grip test values in IDPN treated mice was indicative of a change in the nerve conduction in the forelimb. This was substantiated by an uneven distribution of axonal ncuro-filamcnts. which determine growth of axonal-diamctcrs. and slow axonal transport for impulse conduction. The uneven dispersion of microtubules affected function in normal longitudinal growth and in fast axonal transport: and was a vital sign of nerve degeneration. The orthodox state of mitochondrial conformation indicates ADP deficiency. Reversal to a condensed state (EMF treated. Group 2) corresponds to an oxidative phosphon lation reaction and ATP synthesis, dependent on ADR and proton permeability of mitochondria. Thus. Group 3. poisoned but not treated, showed reduced metabolic activity. Whereas, the condensed state of mitochondria in Group 2 (IDPN +EMF) indicated a mctabolically active condition in axons and Schwann cells. In a previous study at Cornell, excised pieces of sciatic nerves of mice in-vitro culture medium maintained a normal myclin sheath structure and grew longer and wider) during EMF exposure. (12) This could be attributed to Schwann cell activity, a source of ncurotropin for nerve growth. Schwann cells produce poly-peptidc nerve growth factors (NGF). Nerve injury induces an increased output of NGF from Schwann cells. In the in-vivo study, two sources of NGF were available, one from CNS neurons and the other from Schwann cells. EMF exposure may have enhanced the action of Schwann cells in IDPN treated Group 2 mice. These Schwann cells indicated distinct Golgi bodies (GO) that arc the source of NGF secretion, resulting in the remyclination of axons. Indeed, a link between EMF and rcnormalizcd Schwann cell function indicated that a non-ncuronal control in the regeneration and growth of peripheral nerve fibers arc definitely possible, i.e. the microscopic or quantum field regulation through inter-atomic and intcr-molccular communications networks were regulated by EMF. The rcnonnali/cd. physiological state of mitochondria, as observed, indicated its normal membrane permeability and a recovery of ATP synthesis essential for nerve growth and repair. Other ATP dependent processes such as the organization of ncuro-filamcnts and microtubulcs for axonal slow and fast transport systems w ere also restored. The molecular signaling across an axonal membrane may be extensively modified by a low energy level of an applied EMF. and is attainable by cooperative amplification that can restore cellular function. A role of PTEMF (for humans) in recovery from nerve injury, spinal cord traumas, and peripheral neuropathies may be postulated on the basis of selectively modulating neurotropins and their receptors with PTEMF resonant energies. Conclusion The nerve regeneration studies were first conducted at the Wcill Medical College of Cornell University in New York City, under the direction of Professor Brij B. Saxcna (discoverer of the early pregnancy test) and then replicated at Fairlcigh Dickinson University under the direction of evolutionary neu-roscicntist Professor. Anjali Saxcna. Professors Brij and Anjali Saxena concluded. "These results are the first to demonstrate a biological effect of EMF in vivo on the restoration of subccllular structures required for nerve impulse conduction and metabolism in nerves and consequently a grip strength recovery from motor neuropathy, under controlled experimental conditions." (2) Prof Jerry Jacobson, theoretical physicist, bio-physicist and medical researcher, is a world-renowned pioneer in the fie Id of bio-electromagnetics. Inventor of40 < patents and author of more than 100 scientific publications, he has lectured on the theory' and practice of.Jacob-son Resonance throughout the world for more than 30 years. He currently serves as ChiefScience Officer for Pico-Tesia Magnetic Therapies, LLC andMagneceutical Health. LLC. Also, his latest book, "Reason for Life, " a compendium of his art, science, poetry and philosophy is available through www.AbbottPress.com as well as other booksellers. References: C 'olien, D.. (1972) Detection of the Brain s Electrical Activity with a Superconducting Magnetometer, Science 175:664 SaxenaA, Jacobson JI. Yamanashi U'S. Sherlag RJ. LamherthJ, Saxena BB (2003) A hypothetical mathematical construct explaining the mechanism ofbiological amplification in an experimental model utilizing pica tesla (pT) electromagnetic fields. (2003), Medical Hypothesis, 60 (6) p. 821-839, El sevier Science, Ltd. Scherlag. B.J.. Yamanashi U'S. Jacobson, J.I.. Hov, Y. Jackman, II'.M. Lazzara, R. (2004). Magnetism and Cardiac Arrhythmias, Cardiology in Re\>iew, 12(2), 85-96, Lippincott Williams and Wilkins Kavaliers \i., Ossenkopp KP; Calcium Channel Involvement in .1 lagnetic Field Inhibition of.\ lorphine Induced Alangesia. \ lau- nyn- Schmieberg's Arch. Pharmacology 1987: 336: 308-315 Papi F. (Jhione S. Rosa C'.. e/Seppia (^. I.uschi F: Exposure to os cillating Magnetic Fields Influences Sensitivity to Electrical Stimuli: Experiments on Humans. Bio electromagnetics 1995; 16:295-300. Pralo FS, Carson JL, Ossenkopp KP. Kavaliers M; Possible Mechanisms by which extremely low frequency magnetic fields affect opioidfunction. 1ASEB1. 1995. 9:807-814 Jacobson. JI, GormanR, Yamanashi U'S, Dayton M, Halliwanger S, Saxena BB (2001) Pico-Tesla Range Magnetic Fields Tested in Four Site Double Blind Clinical Study for Treatment ofOsteoar- thritic Knees, Estratto Da Gazzetta .\ ledica Italiana Archivo Per Le Science Mediche. (160) 1-21. Exiizioni Minerva Medico. Torino Chao 0., Evans JM. Yamanashi US, Scherlag B. Jacobson JI, Foreman RD, Effects on Rals of low intensity aiulfrecpiency E\ IF stimulation on thoracic spinal neurons receiving noxious cardiac and esophageal inputs: Xeuromodulalion. 205. (8)2: 79-87 Troslel TC. Mclaughlin RM. LamberthJG. Cooper RC. Elder SH, PoolAR, Gao C, CromiakJA. Boyle C Yf (2003) Effects ofpicoTesla Electromagnetic Field treatment on wound healing in rats. Ameri can JI eterinary Research. (64) p. 845-854. Klepitskaya (). Kumar R (2008) Efficacy and Safety of Low U'vel Electromagnetic Field Treatment in Parkinson s Disease. \ lavement Disorders; Yol 23 (11) p. 1628-1637 (Movement Disorder Society) Jacobson JI, Yamanashi U'S, Saxena A. ParekliP, Brown B, Shin D, Saxena BB (2000) Effect of\ lagnetic Fields on \ lice Sciatic Serves In I ilro. Frontier Perspectives 9 (1) p. 6-11 Center for Frontier Sciences at Temple University.
